Hexose-6-phosphate dehydrogenase: a new risk gene for multiple sclerosis.

Journal article

A recent genome-wide association study (GWAS) performed by the The Wellcome Trust Case-Control Consortium based on 12 374 nonsynonymous single-nucleotide polymorphisms (SNPs) provided evidence for several genes involved in multiple sclerosis (MS) susceptibility. In this study, we aimed at verifying the association of 19 SNPs with MS, with P-values < or =0.005, in an independent cohort of 732 patients and 974 controls, all Caucasian from the South of Spain. We observed an association of the...

Expand abstract

Authors: Alcina, A; Ramagopalan, S; Fernández, O; Catalá-Rabasa, A; Fedetz, M

• Publication status: Published
• Journal: European journal of human genetics : EJHG
• Volume: 18
• Issue: 5
• Pages: 618-620
• Publication date: 2010-05-01
• DOI: 10.1038/ejhg.2009.213
• EISSN: 1476-5438
• ISSN: 1018-4813
• Language: English
• Keywords: Cohort Studies; Adult; Spain; Genetic Predisposition to Disease; Great Britain; Case-Control Studies; Polymorphism, Single Nucleotide; Reproducibility of Results; Female; Male; Canada; Humans; Genome-Wide Association Study; Carbohydrate Dehydrogenases; Multiple Sclerosis