The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis.

Journal article

The marked association of abnormalities of chromosome 11 long arm, band q23, with human leukaemia led to the identification of the 11q23 gene called MLL (or HTRX, HRX, TRX1, ALL-1). MLL can become fused with one of a remarkable panoply of genes from other chromosome locations in individual leukaemias, leading to either acute myeloid or lymphoid tumours (hence the name MLL for mixed lineage leukaemia). The unusual finding that a single protein could be involved in both myeloid and lymphoid mal...

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Authors: Daser, A; Rabbitts, T

• Journal: Seminars in cancer biology
• Volume: 15
• Issue: 3
• Pages: 175-188
• Publication date: 2005-06-01
• DOI: 10.1016/j.semcancer.2005.01.007
• EISSN: 1096-3650
• ISSN: 1044-579X
• Language: English
• Keywords: Myeloid-Lymphoid Leukemia Protein; Transcriptional Activation; Animals; Leukemia; Chromosomes; Humans; Bone Marrow; Cell Transformation, Neoplastic