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The CD46-Jagged1 interaction is critical for human T H 1 immunity

Abstract:

CD46 is a complement regulator with important roles related to the immune response. CD46 functions as a pathogen receptor and is a potent costimulator for the induction of interferon-γ (IFN-γ)-secreting effector T helper type 1 (TH1) cells and their subsequent switch into interleukin 10 (IL-10)-producing regulatory T cells. Here we identified the Notch family member Jagged1 as a physiological ligand for CD46. Furthermore, we found that CD46 regulated the expression of Notch receptors and liga...

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Publisher copy:
10.1038/ni.2454

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Journal:
Nature Immunology
Volume:
13
Issue:
12
Pages:
1213-1221
Publication date:
2012-12-01
DOI:
EISSN:
1529-2916
ISSN:
1529-2908
Source identifiers:
366798
Language:
English
Pubs id:
pubs:366798
UUID:
uuid:12d3b728-d2d1-4a86-b9e7-ec10eb1c315b
Local pid:
pubs:366798
Deposit date:
2013-11-16

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