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Journal article

RB regulates the stability and the apoptotic function of p53 via MDM2.

Abstract:

The binding of RB to MDM2 is shown to be essential for RB to overcome both the antiapoptotic function of MDM2 and the MDM2-dependent degradation of p53. The RB-MDM2 interaction does not prevent MDM2 from inhibiting p53-dependent transcription, but the RB-MDM2 complex still binds to p53. Since RB specifically rescues the apoptotic function but not the transcriptional activity of p53 from negative regulation by MDM2, transactivation by wild-type p53 is not required for the apoptotic function of...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
3
Issue:
2
Pages:
181-193
Publication date:
1999-02-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:12cd9e21-4890-4837-ba5e-652a93b73cf8
Source identifiers:
83934
Local pid:
pubs:83934

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