Journal article
Hypertension in pregnancy and in midlife and the risk of dementia: prospective study of 1.3 million UK women
- Abstract:
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INTRODUCTION: Midlife hypertension is associated with dementia risk, although uncertainties remain regarding its association with subtypes and regarding the effect of pregnancy-related hypertension on dementia risk.
METHODS: In the Million Women Study, 1,363,457 women (mean age 57) were asked about current treatment for hypertension and hypertension in pregnancy, and were followed for first hospital record with any mention of dementia. Cox regression yielded hazard ratios (HRs) adjusted for socio-economic, lifestyle and metabolic factors.
RESULTS: With 84,729 dementia cases over 21 years, midlife hypertension was positively associated with dementia (HR 1.17, 95% confidence interval [CI] 1.15-1.19); higher for vascular dementia (HR 1.50; 1.45-1.56) than Alzheimer’s disease (HR 1.01; 0.98-1.04). Hypertension in pregnancy but not in midlife was only weakly associated with dementia (HR 1.04, 1.01-1.06).
DISCUSSION: Midlife hypertension is a strong risk factor for dementia, largely through vascular dementia. Hypertension during pregnancy does not appear to materially affect dementia risk.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 861.3KB, Terms of use)
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- Publisher copy:
- 10.1002/alz.70595
Authors
- Publisher:
- Wiley
- Journal:
- Alzheimer's & Dementia More from this journal
- Volume:
- 21
- Issue:
- 9
- Article number:
- e70595
- Publication date:
- 2025-09-08
- Acceptance date:
- 2025-07-15
- DOI:
- EISSN:
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1552-5279
- ISSN:
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1552-5260
- Language:
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English
- Pubs id:
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2280665
- Local pid:
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pubs:2280665
- Deposit date:
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2025-08-14
Terms of use
- Copyright holder:
- Floud et al
- Copyright date:
- 2025
- Rights statement:
- © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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