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Complexity of trypanosomatid endocytosis pathways revealed by Rab4 and Rab5 isoforms in Trypanosoma brucei.

Abstract:

Small G proteins of the Rab family are responsible for vesicle fusion and control flux during intracellular transport. Rab5 is important in endosome maturation and Rab4 in recycling of endocytic material. Three Rab5 isoforms identified so far in mammals and three in the yeast genome suggest that conservation of multiple Rab5 isoforms is required for sophisticated regulation of endocytosis. Trypanosoma brucei homologues of Rab5 and Rab4 (TbRab5A and TbRab4) have been identified. Here we report...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.273.48.32102

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
The Journal of biological chemistry
Volume:
273
Issue:
48
Pages:
32102-32110
Publication date:
1998-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:12c8dfba-4dda-4682-8d2c-e3264d011fd2
Source identifiers:
8798
Local pid:
pubs:8798

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