Sensitization of tumour cells to lysis by virus-specific CTL using antibody-targeted MHC class I/peptide complexes.

Journal article

A number of cell surface molecules with specificity to tumour cells have been identified and monoclonal antibodies (mAb) to some of these antigens have been used for targeting tumour cells in vivo. We have sought to link the powerful effector mechanisms of cytotoxic T-cells with the specificity of mAb, by targeting recombinant HLA class I molecules to tumour cells using an antibody delivery system. Soluble recombinant MHC class I/peptide complexes including HLA-A2.1 refolded around an immunod...

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Authors: Ogg, G; Dunbar, P; Cerundolo, V; McMichael, A; Lemoine, N

• Publication status: Published
• Journal: British journal of cancer
• Volume: 82
• Issue: 5
• Pages: 1058-1062
• Publication date: 2000-03-01
• DOI: 10.1054/bjoc.1999.1042
• EISSN: 1532-1827
• ISSN: 0007-0920
• Language: English
• Keywords: Flow Cytometry; Peptides; Tumor Cells, Cultured; T-Lymphocytes, Cytotoxic; HLA-A2 Antigen; Recombinant Proteins; Immunotherapy; Lymphoma; Antibodies, Neoplasm; Antibodies, Monoclonal; Antigens, CD20; Drug Delivery Systems; Gene Products, gag; Humans; Biotinylation; Histocompatibility Antigens Class I