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Journal article

IGHV4-39 deletion polymorphism does not associate with risk or outcome of multiple sclerosis.

Abstract:

The restricted use of immunoglobulin heavy chain variable (IGHV) family 4 gene segments by clonally expanded B cells in brain lesions and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is well documented. Specifically, the overrepresentation of gene IGHV4-39 has been highlighted in multiple studies. To investigate the role of IGHV4-39 in MS, we screened 193 MS cases, representing the extremes of clinical outcome (benign and malignant), and 187 controls for a previously reported...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Journal of neuroimmunology
Volume:
225
Issue:
1-2
Pages:
164-166
Publication date:
2010-08-01
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
Source identifiers:
54766
Language:
English
Keywords:
Pubs id:
pubs:54766
UUID:
uuid:12c1e992-6310-416d-b6d6-a99a8875c9cb
Local pid:
pubs:54766
Deposit date:
2012-12-19

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