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IGHV4-39 deletion polymorphism does not associate with risk or outcome of multiple sclerosis.

Abstract:

The restricted use of immunoglobulin heavy chain variable (IGHV) family 4 gene segments by clonally expanded B cells in brain lesions and cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is well documented. Specifically, the overrepresentation of gene IGHV4-39 has been highlighted in multiple studies. To investigate the role of IGHV4-39 in MS, we screened 193 MS cases, representing the extremes of clinical outcome (benign and malignant), and 187 controls for a previously reported...

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Publication status:
Published

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Authors


Watson, CT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Morrison, KM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience, WTC Human Genetics
Journal:
Journal of neuroimmunology
Volume:
225
Issue:
1-2
Pages:
164-166
Publication date:
2010-08-05
DOI:
EISSN:
1872-8421
ISSN:
0165-5728
URN:
uuid:12c1e992-6310-416d-b6d6-a99a8875c9cb
Source identifiers:
54766
Local pid:
pubs:54766

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