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Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats

Abstract:

Short-term consumption of a high-fat diet impairs exercise capacity in both rats and humans, and increases expression of the mitochondrial uncoupling protein, UCP3, in rodent cardiac and skeletal muscle via activation of the transcription factor, peroxisome proliferator-activated receptor (PPAR). Unlike long-chain fatty acids however, medium-chain fatty acids do not activate PPAR and do not increase muscle UCP3 expression. We therefore investigated exercise performance and cardiac mitochondri...

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Publisher copy:
10.1186/1743-7075-8-55

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Journal:
Nutrition and Metabolism
Volume:
8
Publication date:
2011-01-01
DOI:
EISSN:
1743-7075
URN:
uuid:12bfe587-d38e-4359-9346-9ff0bda6da81
Source identifiers:
179203
Local pid:
pubs:179203
Language:
English
Keywords:

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