The immunogenicity and impact on nasopharyngeal carriage of fewer doses of conjugate pneumococcal vaccine immunization schedule.

Journal article

The immunogenicity and impact on carriage of fewer doses of pneumococcal conjugate vaccine (PCV7) followed by booster with pneumococcal polysaccharide vaccine (PPV) were investigated. 684 infants were assigned randomly to one of the three groups that received one (A), two (B) or three (C) doses of PCV7 between 2 and 4 months of age, plus PPV at 10 months. Following primary vaccination protective antibody titers of >0.35 μg/ml against the PCV7 serotypes combined increased significantly with...

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Authors: Ota, M; Akinsola, A; Townend, J; Antonio, M; Enwere, G

• Publication status: Published
• Journal: Vaccine
• Volume: 29
• Issue: 16
• Pages: 2999-3007
• Publication date: 2011-04-01
• DOI: 10.1016/j.vaccine.2011.01.098
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Female; Antibodies, Bacterial; Pneumococcal Vaccines; Pneumococcal Infections; Vaccines, Conjugate; Male; Immunization Schedule; Immunization, Secondary; Nasopharynx; Antibody Formation; Gambia; Infant; Humans