A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected thais

Journal article

Background: CD8+ T cell responses play an important role in the control of HIV-1. The extensive sequence diversity of HIV-1 represents a critical hurdle to developing an effective HIV-1 vaccine, and it is likely that regional-specific vaccine strains will be required to overcome the diversity of the different HIV-1 clades distributed world-wide. Unfortunately, little is known about the CD8+ T cell responses against CRF01_AE, which is responsible for the majority of infections in Southeast Asi...

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Authors: Buranapraditkun, S; Hempel, U; Pitakpolrat, P; Allgaier, R; Thantivorasit, P

• Journal: PLoS ONE
• Volume: 6
• Issue: 8
• Publication date: 2011-01-01
• DOI: 10.1371/journal.pone.0023603
• EISSN: 1932-6203
• Language: English