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Journal article

Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.

Abstract:

N-ethyl-N-nitrosourea (ENU) is a widely used mutagen in genotypic and phenotypic screens aimed at elucidating gene function. The high rate at which ENU induces point mutations raises the possibility that an observed phenotype may be to the result of another unidentified linked mutation. This article presents methods for estimating the probability of additional linked coding mutations (1) in a given region of DNA using both Poisson and Bayesian models and in (2) an F(1) animal exposed to ENU t...

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Publication status:
Published

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Publisher copy:
10.1007/s00335-005-0101-4

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Mammalian genome : official journal of the International Mammalian Genome Society
Volume:
17
Issue:
3
Pages:
230-238
Publication date:
2006-03-01
DOI:
EISSN:
1432-1777
ISSN:
0938-8990
Source identifiers:
33414
Language:
English
Keywords:
Pubs id:
pubs:33414
UUID:
uuid:128ff8dc-d0d7-40a7-a0d3-598a0207d4b0
Local pid:
pubs:33414
Deposit date:
2012-12-19

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