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Journal article

Identification of the domains of neuronal nitric oxide synthase by limited proteolysis.

Abstract:

Nitric oxide synthase (EC 1.14.13.39) binds arginine and NADPH as substrates, and FAD, FMN, tetrahydrobiopterin, haem and calmodulin as cofactors. The protein consists of a central calmodulin-binding sequence flanked on the N-terminal side by a haem-binding region, analogous to cytochrome P-450, and on the C-terminal side by a region homologous with NADPH:cytochrome P-450 reductase. The structure of recombinant rat brain nitric oxide synthase was analysed by limited proteolyis. The products w...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Journal:
Biochemical journal
Volume:
314 ( Pt 1)
Issue:
1
Pages:
55-62
Publication date:
1996-02-01
EISSN:
1470-8728
ISSN:
0264-6021
Source identifiers:
72679

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