Journal article icon

Journal article

Evidence for the early onset of aberrant promoter methylation in urothelial carcinoma.

Abstract:

There is evidence that carcinoma in situ (CIS) is the precursor of invasive urothelial carcinoma, a tumour characterized by frequent gene promoter methylation. The timing of altered DNA methylation is unknown in this pathway. Here we investigate gene methylation in 196 consecutive samples of normal urothelium, CIS, and tumours from 104 patients with both CIS and invasive urothelial carcinoma using quantitative methyl-sensitive polymerase chain reaction for six genes (p16, p14, E-cadherin, RAR...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1002/path.1991

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
Expand authors...
Journal:
Journal of pathology
Volume:
209
Issue:
3
Pages:
336-343
Publication date:
2006-07-01
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
Source identifiers:
120708

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP