Journal article
Evidence for the early onset of aberrant promoter methylation in urothelial carcinoma.
- Abstract:
-
There is evidence that carcinoma in situ (CIS) is the precursor of invasive urothelial carcinoma, a tumour characterized by frequent gene promoter methylation. The timing of altered DNA methylation is unknown in this pathway. Here we investigate gene methylation in 196 consecutive samples of normal urothelium, CIS, and tumours from 104 patients with both CIS and invasive urothelial carcinoma using quantitative methyl-sensitive polymerase chain reaction for six genes (p16, p14, E-cadherin, RAR...
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- Publication status:
- Published
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- Publisher copy:
- 10.1002/path.1991
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Bibliographic Details
- Journal:
- Journal of pathology
- Volume:
- 209
- Issue:
- 3
- Pages:
- 336-343
- Publication date:
- 2006-07-01
- DOI:
- EISSN:
-
1096-9896
- ISSN:
-
0022-3417
- Source identifiers:
-
120708
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:120708
- UUID:
-
uuid:12886fd2-74dd-4d0a-a543-8d736d37669b
- Local pid:
- pubs:120708
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2006
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