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Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknowns.

Abstract:

Fifty years ago, Mary Lyon hypothesised that one of the two X chromosomes in female mammalian cells is inactivated at random during early embryogenesis and that the inactive X is then stably maintained through all subsequent cell divisions. Although Lyon's hypothesis is now widely regarded as fact, we should not forget that her conceptual leap met with considerable resistance from the scientific establishment at the time - a common response to new ideas. Taking this point as a theme, I discus...

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Publication status:
Published

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Publisher copy:
10.1242/dev.065276

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Development (Cambridge, England)
Volume:
138
Issue:
23
Pages:
5057-5065
Publication date:
2011-12-05
DOI:
EISSN:
1477-9129
ISSN:
0950-1991
URN:
uuid:128843d4-3eb4-4713-b734-a389eff10a52
Source identifiers:
205831
Local pid:
pubs:205831

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