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Simultaneous measurement of ionic current and fluorescence from single protein pores.

Abstract:

The ability to simultaneously monitor both the ionic current and fluorescence from membrane channels and pores has the potential to link structural changes with function in such proteins. We present a new method for simultaneously measuring single-channel electrical currents and fluorescence from membrane proteins by using water-in-oil droplet bilayers. We demonstrate the simultaneous fluorescence and electrical detection of stochastic blocking by cyclodextrin in multiple staphylococcal alpha...

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Publication status:
Published

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Publisher copy:
10.1021/ja808128s

Authors


Thompson, JR More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Journal:
Journal of the American Chemical Society
Volume:
131
Issue:
5
Pages:
1652-1653
Publication date:
2009-02-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:1285cfa3-7778-4955-b895-b141bc95c3c6
Source identifiers:
34554
Local pid:
pubs:34554

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