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Journal article

A randomized study comparing combined pneumococcal conjugate and polysaccharide vaccination schedules in adults.

Abstract:

BACKGROUND: The widely used 23-valent plain polysaccharide vaccine (23vP) has limited effectiveness, produces short-lived immune responses, and induces attenuated antibody production after subsequent challenge with pneumococcal vaccines. Our goal was to examine whether priming with the 7-valent pneumococcal conjugate vaccine (PCV7) could enhance the immunogenicity of 23vP for the PCV7 serotypes and to investigate whether 23vP induced hyporesponsiveness could be overcome using PCV7. METHODS: ...

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Publication status:
Published

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Publisher copy:
10.1093/cid/cir003

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Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume:
52
Issue:
6
Pages:
736-742
Publication date:
2011-03-05
DOI:
EISSN:
1537-6591
ISSN:
1058-4838
URN:
uuid:127c363d-a0f2-4c4e-b438-0a389195bf1d
Source identifiers:
119267
Local pid:
pubs:119267

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