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Journal article

Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array.

Abstract:
Optical platforms for assaying membrane protein function offer a promising route to scalable high-throughput screening (see picture). For the first time quantitative measurements of membrane protein inhibition are reported in an optically addressable lipid bilayer array. Wide-field total internal reflection fluorescence (TIRF) imaging of Ca 2+ flux enables the quantification of α-hemolysin inhibition by γ-cyclodextrin. Copyright © 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim.
Publication status:
Published

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Publisher copy:
10.1002/anie.201107343

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
Journal:
Angewandte Chemie (International ed. in English)
Volume:
51
Issue:
13
Pages:
3134-3138
Publication date:
2012-03-05
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
URN:
uuid:127c1472-1ad6-444c-a5ef-7c789d34229a
Source identifiers:
254911
Local pid:
pubs:254911

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