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A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1

Abstract:: To identify new susceptibility loci for psoriasis, we undertOk a genome-wide asociation study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified asociations at eight previously unreported genomic loci. Seven loci harbored genes with recognized iMune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These asociations were replicated in 9,079 European samples (six loci with a combined P < 5-10 -8 and two loci with a combined P < 5-10-7). ...
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APA Style

Strange, A., Capon, F., Spencer, C., Knight, J., Weale, M., Allen, M., Barton, A., Band, G., Bellenguez, C., Bergboer, J., BlackweL, J., Bramon, E., Bumpstead, S., Casas, J., Cork, M., Corvin, A., Deloukas, P., Dilthey, A., Duncanson, A., … Gray, E. (2010). A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1. Nature Genetics, 42(11), 985–990.

MLA Style

Strange, A., et al. “A Genome-Wide Asociation Study Identifies New Psoriasis Susceptibility Loci and an Interaction BetwEn HLA-C and ERAP1.” Nature Genetics, vol. 42, no. 11, 2010, pp. 985–90.

Chicago Style

Strange, A, F Capon, C Spencer, J Knight, M Weale, M Allen, A Barton, et al. 2010. “A Genome-Wide Asociation Study Identifies New Psoriasis Susceptibility Loci and an Interaction BetwEn HLA-C and ERAP1.” Nature Genetics 42 (11): 985–90.
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Publisher copy:: 10.1038/ng.694

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+ Strange, A More by this author

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+ Capon, F More by this author

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+ Spencer, C More by this author

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+ Knight, J More by this author

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+ Weale, M More by this author

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Bibliographic Details

Journal:: Nature Genetics
Volume:: 42
Issue:: 11
Pages:: 985-990
Publication date:: 2010-11-01
DOI:: 10.1038/ng.694
EISSN:: 1546-1718
ISSN:: 1061-4036

Item Description

Language:: English
Pubs id:: pubs:103537
UUID:: uuid:1273a693-058f-42f6-8f40-7b95564e866f
Local pid:: pubs:103537
Source identifiers:: 103537
Deposit date:: 2012-12-19

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Copyright date:: 2010

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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