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Journal article

Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.

Abstract:

Naturally occurring CD4+ regulatory T cells (T(R)) that express CD25 and the transcription factor FoxP3 play a key role in immune homeostasis, preventing immune pathological responses to self and foreign Ags. CTLA-4 is expressed by a high percentage of these cells, and is often considered as a marker for T(R) in experimental and clinical analysis. However, it has not yet been proven that CTLA-4 has a direct role in T(R) function. In this study, using a T cell-mediated colitis model, we demons...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.177.7.4376

Authors


Greenwald, R More by this author
Robinson, N More by this author
Mandelbrot, D More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
177
Issue:
7
Pages:
4376-4383
Publication date:
2006-10-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:1271de28-2476-416b-81bc-d624cd0d5408
Source identifiers:
17543
Local pid:
pubs:17543

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