- Abstract:
-
Naturally occurring CD4+ regulatory T cells (T(R)) that express CD25 and the transcription factor FoxP3 play a key role in immune homeostasis, preventing immune pathological responses to self and foreign Ags. CTLA-4 is expressed by a high percentage of these cells, and is often considered as a marker for T(R) in experimental and clinical analysis. However, it has not yet been proven that CTLA-4 has a direct role in T(R) function. In this study, using a T cell-mediated colitis model, we demons...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.177.7.4376
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 177
- Issue:
- 7
- Pages:
- 4376-4383
- Publication date:
- 2006-10-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:1271de28-2476-416b-81bc-d624cd0d5408
- Source identifiers:
-
17543
- Local pid:
- pubs:17543
- Language:
- English
- Keywords:
- Copyright date:
- 2006
Journal article
Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo.
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