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Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.

Abstract:

Cytotoxic T lymphocytes (CTL) play a central role in containment of HIV infection. Evasion of the immune response by CTL escape is associated with progression to disease. It is therefore hypothesised that transmitted viruses encode escape mutations within epitopes that are required for successful control of viraemia. In order to test this hypothesis, escape through the dominant HLA-A2-restricted CTL epitope SLYNTVATL (p17 Gag residues 77-85 SL9) in the setting of mother-to-child-transmission ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Pasquier, C More by this author
Holmes, EC More by this author
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Volume:
79
Issue:
1-2
Pages:
109-116
Publication date:
2001-11-05
DOI:
EISSN:
1879-0542
ISSN:
0165-2478
URN:
uuid:12656938-725d-40da-8885-e94fa5cd786b
Source identifiers:
28478
Local pid:
pubs:28478

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