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The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists

Abstract:

Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in murine neutrophils, in comparison to well-established NLRP3 signalling pathways in macrophages. Here, we demonstrate that while murine neutrophils can indeed signal via the NLRP3 inf...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/eji.201545943

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, KIR
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Publisher:
Wiley Online Library Publisher's website
Journal:
European journal of immunology Journal website
Volume:
46
Issue:
4
Pages:
1004-1010
Publication date:
2016-04-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:1263a166-0b9a-4e92-803b-dbb8305146c5
Source identifiers:
627575
Local pid:
pubs:627575

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