Neutrophils express pattern recognition receptors (PRRs) and regulate immune responses via PRR-dependent cytokine production. An emerging theme is that neutrophil PRRs often exhibit cell type-specific adaptations in their signalling pathways. This prompted us to examine inflammasome signalling by the PRR NLRP3 in murine neutrophils, in comparison to well-established NLRP3 signalling pathways in macrophages. Here, we demonstrate that while murine neutrophils can indeed signal via the NLRP3 inf...Expand abstract
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- This is the peer reviewed version of the following article: "The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists", which has been published in final form at 10.1002/eji.201545943. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists
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