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Journal article

Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.

Abstract:

Matrix metalloproteinase (MMP)-13 is one of the mammalian collagenases that play key roles in tissue remodelling and repair and in progression of diseases such as cancer, arthritis, atherosclerosis, and aneurysm. For collagenase to cleave triple helical collagens, the triple helical structure has to be locally unwound before hydrolysis, but this process is not well understood. We report crystal structures of catalytically inactive full-length human MMP-13(E223A) in complex with peptides of 14...

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Publication status:
Published

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Publisher copy:
10.1096/fj.13-233601

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
27
Issue:
11
Pages:
4395-4405
Publication date:
2013-11-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Source identifiers:
416281
Language:
English
Keywords:
Pubs id:
pubs:416281
UUID:
uuid:126275fe-cfdb-49a6-836c-d88d7dccc59d
Local pid:
pubs:416281
Deposit date:
2013-11-16

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