Journal article icon

Journal article

Crystal structure of full-length human collagenase 3 (MMP-13) with peptides in the active site defines exosites in the catalytic domain.

Abstract:

Matrix metalloproteinase (MMP)-13 is one of the mammalian collagenases that play key roles in tissue remodelling and repair and in progression of diseases such as cancer, arthritis, atherosclerosis, and aneurysm. For collagenase to cleave triple helical collagens, the triple helical structure has to be locally unwound before hydrolysis, but this process is not well understood. We report crystal structures of catalytically inactive full-length human MMP-13(E223A) in complex with peptides of 14...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1096/fj.13-233601

Authors


Cuniasse, P More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
27
Issue:
11
Pages:
4395-4405
Publication date:
2013-11-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:126275fe-cfdb-49a6-836c-d88d7dccc59d
Source identifiers:
416281
Local pid:
pubs:416281

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP