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Linkage and association studies of single-nucleotide polymorphism-tagged tumor necrosis factor haplotypes in juvenile oligoarthritis.

Abstract:

OBJECTIVE: The presence of increased levels of tumor necrosis factor (TNF) in serum and synovial fluid of patients and the encouraging outcome of anti-TNF therapy have implicated TNFalpha in the etiopathogenesis of juvenile oligoarthritis. Although the locus is polymorphic, no study has investigated all TNF single-nucleotide polymorphisms (SNPs) with respect to disease. The aim of this study was to examine the association of multiple TNF SNPs with juvenile oligoarthritis and to construct and...

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Publisher copy:
10.1002/art.10698

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Journal:
Arthritis and rheumatism
Volume:
46
Issue:
12
Pages:
3304-3311
Publication date:
2002-12-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:125b1937-102f-440d-b1e2-0de87ef1da20
Source identifiers:
316513
Local pid:
pubs:316513

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