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Lipid bilayer deformation and the free energy of interaction of a Kv channel gating-modifier toxin.

Abstract:

A number of membrane proteins act via binding at the water/lipid bilayer interface. An important example of such proteins is provided by the gating-modifier toxins that act on voltage-gated potassium (Kv) channels. They are thought to partition to the headgroup region of lipid bilayers, and so provide a good system for probing the nature of interactions of a protein with the water/bilayer interface. We used coarse-grained molecular dynamics simulations to compute the one-dimensional potential...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.108.130971

Authors


Gavaghan, D More by this author
Sansom, MS More by this author
Journal:
Biophysical journal
Volume:
95
Issue:
8
Pages:
3816-3826
Publication date:
2008-10-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:1259cfa4-dfdd-4631-b27a-6bcded508ef8
Source identifiers:
100574
Local pid:
pubs:100574

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