The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England and Wales and Finland: seasonality and cross-protection.

Journal article

Human respiratory syncytial virus (hRSV) transmission dynamics are inherently cyclical, and the observed genetic diversity (between groups A and B) also appears to have a repeating pattern. A key unknown is the extent to which genetic variants interact immunologically, and thus impact on epidemiology. We developed a novel mathematical model for hRSV transmission including seasonal forcing of incidence and temporary intra- and inter-group partial immunity. Simultaneous model fits to data from ...

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Authors: White, L; Waris, M; Cane, P; Nokes, D; Medley, G

• Publication status: Published
• Journal: Epidemiology and infection
• Volume: 133
• Issue: 2
• Pages: 279-289
• Publication date: 2005-04-01
• DOI: 10.1017/s0950268804003450
• EISSN: 1469-4409
• ISSN: 0950-2688
• Language: English
• Keywords: Child; Adolescent; Adult; Wales; Infant, Newborn; Respiratory Syncytial Viruses; Genetic Variation; Aged; Seasons; Models, Theoretical; Incidence; Female; Middle Aged; England; Humans; Forecasting; Child, Preschool; Respiratory Syncytial Virus Infections; Infant; Male