- Abstract:
-
Forces determining the rate of spread of drug resistance in malaria were explored using a genetics transmission model which took account of the strong population structure of these parasites. The rate of change of frequency of drug resistant mutants in the parasite population is primarily a function of the proportion of hosts treated with drugs, and parasite transmission rates. With high transmission rates, selection by drugs is more effective than with lower rates because the resistant mutan...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/s0035-9203(98)90745-3
-
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- Journal:
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Volume:
- 92
- Issue:
- 2
- Pages:
- 188-195
- Publication date:
- 1998
- DOI:
- EISSN:
-
1878-3503
- ISSN:
-
0035-9203
- URN:
-
uuid:125344af-466a-451b-b49d-0a2cb88f8617
- Source identifiers:
-
90603
- Local pid:
- pubs:90603
- Language:
- English
- Keywords:
- Copyright date:
- 1998
Journal article
The evolution of multiple drug resistance in malaria parasites.
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