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Genomic studies of gene expression: regulation of the Wilson disease gene.

Abstract:

Bacterial artificial chromosomes (BACs) have many advantages over other large-insert cloning vectors and have been used for a variety of genetic applications, including the final contigs of the human genome. We describe the utilization of a BAC construct to study gene regulation in a tissue culture-based system, using a 170-kb clone containing the entire Wilson disease (WND) locus as a model. A second BAC construct that lacked a putative negatively regulating promoter sequence was created. A ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
Journal:
Genomics
Volume:
81
Issue:
6
Pages:
531-542
Publication date:
2003-06-01
DOI:
EISSN:
1089-8646
ISSN:
0888-7543
Source identifiers:
32372

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