Journal article
Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial
- Abstract:
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Background: OXi4503 is a tubulin-binding vascular disrupting agent that has recently completed a Cancer Research UK-sponsored phase I trial. Preclinical studies demonstrated early drug-induced apoptosis in tumour endothelial cells at 1-3 h and secondary tumour cell necrosis between 6 and 72 h. Methods: To capture both possible outcomes of OXi4503 treatment on cell death, plasma samples for analysis by M30 and M65 ELISAs, which measure different circulating forms of cytokeratin 18 as biomarker...
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- Publisher copy:
- 10.1038/bjc.2012.165
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Authors
Bibliographic Details
- Journal:
- British Journal of Cancer
- Volume:
- 106
- Issue:
- 11
- Pages:
- 1766-1771
- Publication date:
- 2012-05-22
- DOI:
- EISSN:
-
1532-1827
- ISSN:
-
0007-0920
- Source identifiers:
-
335181
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:335181
- UUID:
-
uuid:1243d56e-d10c-4a31-bd38-5f0ad1410a4b
- Local pid:
- pubs:335181
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2012
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