Journal article icon

Journal article

Quantitative rate measurement of the hydroxide driven dissolution of an enteric drug coating using atomic force microscopy

Abstract:

The hydroxide-driven dissolution of the polymer hydroxypropyl methylcellulose phthalate (HPMCP) in aqueous solution is studied using atomic force microscopy. The novel technique of employing the surface-averaged z-piezo voltage as a direct measure of the mean absolute surface height is described, so as, after appropriate calibration, to permit the ready inference of dissolution fluxes. In the case of interest the following dissolution rate law was established: j/g·cm-2·s-1 = 105.0[OH-] over t...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1021/la961094m

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Physical & Theoretical Chem
Role:
Author
Journal:
LANGMUIR
Volume:
13
Issue:
12
Pages:
3080-3083
Publication date:
1997-06-11
DOI:
EISSN:
1520-5827
ISSN:
0743-7463
Source identifiers:
45617
Language:
English
UUID:
uuid:123d909e-a5a8-4364-a36c-1c5940421276
Local pid:
pubs:45617
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP