Journal article icon

Journal article

Truncated CPSF6 forms higher order complexes that bind and disrupt HIV-1 capsid

Abstract:

Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-1 capsid and mediates nuclear transport and integration targeting of HIV-1 pre-integration complexes. Truncation of the protein at its C-terminal nuclear-targeting arginine/serine-rich (RS-) domain produces a protein, CPSF6-358, that potently inhibits HIV-1 infection by targeting the capsid and inhibiting nuclear entry. To understand the molecular mechanism behind this restriction, the interaction betw...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

Actions


Access Document


Files:
Publisher copy:
10.1128/jvi.00368-18

Authors


Fischer, DK More by this author
Watkins, SC More by this author
Expand authors...
More from this funder
Funding agency for:
Zhang, P
Publisher:
American Society for Microbiology Publisher's website
Journal:
Journal of Virology Journal website
Volume:
92
Issue:
13
Pages:
Article: e00368-18
Publication date:
2018-04-11
Acceptance date:
2018-04-11
DOI:
ISSN:
0022-538X and 1098-5514
Pubs id:
pubs:843815
URN:
uri:1237581d-604c-43a1-a389-87b7bc34262b
UUID:
uuid:1237581d-604c-43a1-a389-87b7bc34262b
Local pid:
pubs:843815
Language:
English
Keywords:

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP