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Journal article

CLEAVAGE OF THE 5-AMINO-5-CARBOXY-2-OXAPENTANOYL SIDE-CHAIN FROM ENZYMATICALLY SYNTHESIZED PENICILLINS AND CEPHALOSPORINS

Abstract:
Both 5R- and 5S-5-amino-5-carboxy-2-oxapentanoyl side chains can substitute for the L-δ-α-aminoadipoyl side chain in the isopenicillin N synthase catalysed formation of penicillins from tripeptides. The 5R- side chain analogue can be cleaved from penicillins and cephalosporins by treatment with D-amino acid oxidase followed by oxidative decarboxylation and decarboxylative elimination. © 1995.
Publication status:
Published

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Authors


BALDWIN, J More by this author
FORREST, A More by this author
SCHOFIELD, C More by this author
Journal:
BIOORGANIC and MEDICINAL CHEMISTRY LETTERS
Volume:
5
Issue:
21
Pages:
2507-2512
Publication date:
1995-11-02
DOI:
ISSN:
0960-894X
URN:
uuid:122c8961-226b-4349-9edf-5fc0a8893075
Source identifiers:
44903
Local pid:
pubs:44903
Language:
English

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