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Humanization of an anti-mucin antibody for breast and ovarian cancer therapy.

Abstract:

Antibody-drug conjugates utilize the targetting potential of antibodies to improve the potential of cytostatic or cytocidal drugs. One such murine monoclonal antibody, CTM01 (mCTM01), which recognizes an epitope on breast epithelial mucin, has potential for the treatment of breast and ovarian cancers. We examine in this paper the comparative properties of mCTM01 against a number of other anti-mucin antibodies. We then describe the humanization and high level re-expression of humanized CTM01 (...

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Publication status:
Published

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Authors


Caskey-Finney, HM More by this author
Lawson, AD More by this author
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Journal:
Advances in experimental medicine and biology
Volume:
353
Pages:
61-82
Publication date:
1994
ISSN:
0065-2598
URN:
uuid:121a7aea-9670-4a87-8e88-8bfc9eb1bbf6
Source identifiers:
171611
Local pid:
pubs:171611

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