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The effects of host immunity on virulence-transmissibility relationships in the rodent malaria parasite Plasmodium chabaudi.

Abstract:

Here we examined the impact of host immunity on relationships between parasite virulence, transmission rate, intrinsic growth rate and host recovery rate in the rodent malaria parasite, Plasmodium chabaudi. Groups of naïve and immunized mice were infected with 1 of 10 cloned lines of parasites and their infection dynamics were monitored for 19 days. We found that (1) host immunity reduced the growth rate, virulence, transmission rate and infection length, with a consequent 3-fold reduction in...

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Publication status:
Published

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Publisher copy:
10.1017/s003118200200272x

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Journal:
Parasitology
Volume:
126
Issue:
Pt 2
Pages:
103-112
Publication date:
2003-02-05
DOI:
EISSN:
1469-8161
ISSN:
0031-1820
URN:
uuid:1216b66c-62ac-4761-ab26-b75661fc2ff7
Source identifiers:
90471
Local pid:
pubs:90471

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