Journal article
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?
- Abstract:
-
The importance of tumour necrosis factor (TNF)alpha in rheumatoid arthritis (RA) was initially proposed on the basis of analysis of cytokine gene regulation at the local site of the disease, the synovium. This was then verified in animal models and established in an extensive series of clinical trials, culminating in now 250000 treated patients with either of two approved TNF inhibitors, antibody or fusion protein. The degree and magnitude of clinical benefit has enabled analyses of the mecha...
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Bibliographic Details
- Journal:
- Novartis Foundation symposium
- Volume:
- 256
- Pages:
- 53-269
- Publication date:
- 2004-01-01
- EISSN:
-
1935-4657
- ISSN:
-
1528-2511
- Source identifiers:
-
224029
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:224029
- UUID:
-
uuid:12152fdd-9a93-4762-92dc-72ac594f98fb
- Local pid:
- pubs:224029
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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