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Journal article

Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?

Abstract:

The importance of tumour necrosis factor (TNF)alpha in rheumatoid arthritis (RA) was initially proposed on the basis of analysis of cytokine gene regulation at the local site of the disease, the synovium. This was then verified in animal models and established in an extensive series of clinical trials, culminating in now 250000 treated patients with either of two approved TNF inhibitors, antibody or fusion protein. The degree and magnitude of clinical benefit has enabled analyses of the mecha...

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Journal:
Novartis Foundation symposium
Volume:
256
Pages:
53-269
Publication date:
2004-01-01
EISSN:
1935-4657
ISSN:
1528-2511
Source identifiers:
224029
Language:
English
Keywords:
Pubs id:
pubs:224029
UUID:
uuid:12152fdd-9a93-4762-92dc-72ac594f98fb
Local pid:
pubs:224029
Deposit date:
2012-12-19

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