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Severe but reversible neuropathy and encephalopathy due to vitamin E deficiency

Abstract:
Vitamin E deficiency is known to result mainly in a spinocerebellar syndrome and involvement of the peripheral nervous system occurs less commonly. Most cases of vitamin E-deficient ataxic neuropathy reported relate to a genetically-mediated cause through mutation of the alpha-tocopherol transfer protein (TTPA) gene on chromosome 8q13 [1]. Severe subacute adult-onset rapidly disabling neuropathy due to vitamin E deficiency is not to our knowledge reported. Cognitive dysfunction is uncommon in this setting. Occurrence of isolated ymptomatic vitamin E deficiency due to pancreatic exocrine insufficiency (PEI) appears exceptional.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.clineuro.2017.06.005

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author


Publisher:
Elsevier
Journal:
Clinical Neurology and Neurosurgery More from this journal
Volume:
160
Pages:
19-20
Publication date:
2017-06-08
Acceptance date:
2017-06-06
DOI:
ISSN:
0303-8467


Language:
English
Keywords:
Pubs id:
810295
Local pid:
pubs:810295
Deposit date:
2020-04-22

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