Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.

Journal article

1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of the Vd of digoxin. 5 Digoxin requirements may be predictable before therapy commences if IC50 measurements are performed.

Authors: Aronson, J; Grahame-Smith, D

• Publication status: Published
• Journal: British journal of clinical pharmacology
• Volume: 4
• Issue: 2
• Pages: 223-227
• Publication date: 1977-04-01
• DOI: 10.1111/j.1365-2125.1977.tb00698.x
• EISSN: 1365-2125
• ISSN: 0306-5251
• Language: English
• Keywords: Middle Aged; Radioisotopes; Aged; Male; Rubidium; Erythrocytes; Regression Analysis; Kinetics; Adult; Methods; Humans; Models, Biological; Female; Age Factors; Digoxin