Journal article icon

Journal article

Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.

Abstract:

1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of t...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Primary Care Health Sciences, PHC-Seniors
Grahame-Smith, DG More by this author
Journal:
British journal of clinical pharmacology
Volume:
4
Issue:
2
Pages:
223-227
Publication date:
1977-04-05
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
URN:
uuid:12056533-eb02-4388-ab53-d63a1da4acd9
Source identifiers:
322128
Local pid:
pubs:322128

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP