- Abstract:
-
1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of t...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/j.1365-2125.1977.tb00698.x
-
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- Journal:
- British journal of clinical pharmacology
- Volume:
- 4
- Issue:
- 2
- Pages:
- 223-227
- Publication date:
- 1977-04-05
- DOI:
- EISSN:
-
1365-2125
- ISSN:
-
0306-5251
- URN:
-
uuid:12056533-eb02-4388-ab53-d63a1da4acd9
- Source identifiers:
-
322128
- Local pid:
- pubs:322128
- Language:
- English
- Keywords:
- Copyright date:
- 1977
Journal article
Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.
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