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Monitoring digoxin therapy: II. Determinants of the apparent volume of distribution.

Abstract:

1 In eighteen subjects receiving digoxin therapy the apparent volume of distribution (Vd) of the drug has been calculated. 2 For each subject the sensitivity of the 86Rb transport mechanism of his pre-treatment erythrocytes to in vitro inhibition by digoxin has been measured (IC50). 3 The Vd of digoxin correlates both with the age of the patients and with the IC50 of their pre-treatment erythrocytes. 4 The implications of these findings are discussed in terms of the possible determinants of t...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Journal:
British journal of clinical pharmacology
Volume:
4
Issue:
2
Pages:
223-227
Publication date:
1977-04-01
DOI:
EISSN:
1365-2125
ISSN:
0306-5251
Source identifiers:
322128
Language:
English
Keywords:
Pubs id:
pubs:322128
UUID:
uuid:12056533-eb02-4388-ab53-d63a1da4acd9
Local pid:
pubs:322128
Deposit date:
2012-12-19

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