Response to highly active antiretroviral therapy varies with age: the UK and Ireland Collaborative HIV Paediatric Study.

Journal article

OBJECTIVE: To evaluate the effect of age, CD4 percentage (CD4%) and plasma HIV-1 RNA on response to highly active antiretroviral therapy (HAART) in previously untreated children. DESIGN: Cohort study. METHODS: We examined the association between age at HAART initiation, and CD4 and HIV-1 RNA response using logistic and Cox regression, adjusting for sex, route of infection and pre-HAART values. RESULTS: CD4% increases of > 10% at 6 months were more likely in younger children [odds ratio (OR...

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Authors: Walker, A; Doerholt, K; Sharland, M; Gibb, D

• Publication status: Published
• Journal: AIDS (London, England)
• Volume: 18
• Issue: 14
• Pages: 1915-1924
• Publication date: 2004-09-01
• DOI: 10.1097/00002030-200409240-00007
• EISSN: 1473-5571
• ISSN: 0269-9370
• Language: English
• Keywords: HIV-1; Child, Preschool; Infant, Newborn; Viral Load; CD4-Positive T-Lymphocytes; Great Britain; Infant; Antiretroviral Therapy, Highly Active; RNA, Viral; Age Factors; Collaborative HIV Paediatric Study (CHIPS) Steering Committee; HIV Infections; Humans; Ireland; CD4 Lymphocyte Count; Child; Cohort Studies