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Journal article

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans.

Abstract:

Protective immunity against influenza virus infection is mediated by neutralizing antibodies, but the precise role of T cells in human influenza immunity is uncertain. We conducted influenza infection studies in healthy volunteers with no detectable antibodies to the challenge viruses H3N2 or H1N1. We mapped T cell responses to influenza before and during infection. We found a large increase in influenza-specific T cell responses by day 7, when virus was completely cleared from nasal samples ...

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Publication status:
Published

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Publisher copy:
10.1038/nm.2612

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Journal:
Nature medicine
Volume:
18
Issue:
2
Pages:
274-280
Publication date:
2012-02-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
Source identifiers:
314035

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