Journal article icon

Journal article

Replicative DNA polymerase mutations in cancer.

Abstract:

Three DNA polymerases - Pol α, Pol δ and Pol ɛ - are essential for DNA replication. After initiation of DNA synthesis by Pol α, Pol δ or Pol ɛ take over on the lagging and leading strand respectively. Pol δ and Pol ɛ perform the bulk of replication with very high fidelity, which is ensured by Watson-Crick base pairing and 3'exonuclease (proofreading) activity. Yeast models have shown that mutations in the exonuclease domain of Pol δ and Pol ɛ homologues can cause a mutator phenotype. Recently...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1016/j.gde.2013.12.005

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Current opinion in genetics and development
Volume:
24
Issue:
1
Pages:
107-113
Publication date:
2014-02-05
DOI:
EISSN:
1879-0380
ISSN:
0959-437X
URN:
uuid:11fc0afd-f9d0-41e8-b988-d4c3e69ebf48
Source identifiers:
451127
Local pid:
pubs:451127

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP