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Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate.

Abstract:

Cell-penetrating peptides (CPPs) are membrane permeable vectors recognized for their intrinsic ability to gain access to the cell interior. The hydrophobic counter-anion, pyrenebutyrate, enhances cellular uptake of oligoarginine CPPs. To elucidate CPP uptake mechanisms, the effect of pyrenebutyrate on well-recognized CPPs with varying hydrophobicity and arginine content is investigated. The cellular CPP uptake and CPP-mediated oligonucleotide delivery is analyzed by fluorescence activated cel...

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Authors


Guterstam, P More by this author
Takeuchi, T More by this author
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Journal:
Biochimica et biophysica acta
Volume:
1788
Issue:
12
Pages:
2509-2517
Publication date:
2009-12-05
DOI:
ISSN:
0006-3002
URN:
uuid:11f5fc9c-2095-4a65-aaba-05f195eb3b9e
Source identifiers:
273988
Local pid:
pubs:273988

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