Journal article

The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Abstract:: The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.

Publication status:: Published

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APA Style

Napier, S., Wishart, G., Arbuckle, W., Baker, J., Barn, D., Bingham, M., Brown, A., Byford, A., Claxton, C., Craighead, M., Buchanan, K., Fielding, L., Gibson, L., Goodwin, R., Goutcher, S., Irving, N., MacSweeney, C., Milne, R., Mort, C., … Young, T. (2011). The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 21(10), 3163–3167.

MLA Style

Napier, S, et al. “The Discovery of Novel 8-Azabicyclo[3.2.1]Octan-3-Yl)-3-(4-Chlorophenyl) Propanamides as Vasopressin V1A Receptor Antagonists.” Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 10, 2011, pp. 3163–67.

Chicago Style

Napier, S, G Wishart, W Arbuckle, et al. 2011. “The Discovery of Novel 8-Azabicyclo[3.2.1]Octan-3-Yl)-3-(4-Chlorophenyl) Propanamides as Vasopressin V1A Receptor Antagonists.” Bioorganic and Medicinal Chemistry Letters 21 (10): 3163–67.
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Publisher copy:: 10.1016/j.bmcl.2011.02.096

Authors

+ Napier, S More by this author

Role:: Author

+ Wishart, G More by this author

Role:: Author

+ Arbuckle, W More by this author

Role:: Author

+ Baker, J More by this author

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+ Barn, D More by this author

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Journal:: Bioorganic and medicinal chemistry letters More from this journal
Volume:: 21
Issue:: 10
Pages:: 3163-3167
Publication date:: 2011-05-01
DOI:: 10.1016/j.bmcl.2011.02.096
EISSN:: 1464-3405
ISSN:: 0960-894X

Language:: English
Keywords:: Protein Binding

Cells, Cultured

Receptors, Vasopressin

Amides

Liver

Cyclization

Drug Discovery

Humans

Molecular Structure

Aza Compounds
Pubs id:: pubs:440028
UUID:: uuid:11f4bb58-1ea8-4225-b24f-4afeae94fec4
Local pid:: pubs:440028
Source identifiers:: 440028
Deposit date:: 2013-12-13
ARK identifier:: ark:/29072/ora_11f4bb581ea84225b24f4afeae94fec4

Terms of use

Copyright date:: 2011

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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