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The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V1A receptor antagonists.

Abstract:
The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
Publication status:
Published

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Publisher copy:
10.1016/j.bmcl.2011.02.096

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Journal:
Bioorganic and medicinal chemistry letters
Volume:
21
Issue:
10
Pages:
3163-3167
Publication date:
2011-05-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Source identifiers:
440028
Language:
English
Keywords:
Pubs id:
pubs:440028
UUID:
uuid:11f4bb58-1ea8-4225-b24f-4afeae94fec4
Local pid:
pubs:440028
Deposit date:
2013-12-13

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