The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides.

Journal article

A proportion of cytotoxic T lymphocytes (CTL) responding to infection by influenza recognize target cells that express the viral nucleoprotein. Recent work showed that CTL can recognize short overlapping regions of large nucleoprotein fragments expressed in transfected L cells. This led to the suggestion that CTL recognize segmental epitopes of denatured or degraded proteins in a similar way to helper T cells. One corollary of this idea is that CTL should recognize appropriate short peptides ...

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Authors: Townsend, A; Rothbard, J; Gotch, F; Bahadur, G; Wraith, D

• Publication status: Published
• Journal: Cell
• Volume: 44
• Issue: 6
• Pages: 959-968
• Publication date: 1986-03-01
• DOI: 10.1016/0092-8674(86)90019-x
• EISSN: 1097-4172
• ISSN: 0092-8674
• Language: English
• Keywords: Humans; Amino Acid Sequence; Alleles; Antibodies, Monoclonal; T-Lymphocytes, Cytotoxic; Nucleoproteins; Epitopes; Mice, Inbred C57BL; Mice; Major Histocompatibility Complex; Animals; Peptides; Viral Proteins; Cell Division; Cytotoxicity, Immunologic; Orthomyxoviridae