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Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.

Abstract:

BACKGROUND: Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical development and optimization of recombinant human and simian adenoviral (AdHu5 and ChAd63) and orthopoxviral (MVA) vectors encoding transgene inserts for Plasmodium falciparum AMA1 (PfAMA1). METHODOLOGY/PRINCIPAL FINDINGS: AdHu5-MVA prime...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0020977

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
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Institution:
University of Oxford
Remarque, EJ More by this author
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Funding agency for:
Biswas, S
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Funding agency for:
Biswas, S
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Funding agency for:
Gilbert, SC
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Funding agency for:
Hill, AV
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
6
Pages:
Article: e20780
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:11dc1418-d75a-4490-a1aa-3a6fa7b508fc
Source identifiers:
154023
Local pid:
pubs:154023

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