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Journal article

Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.

Abstract:

BACKGROUND: Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical development and optimization of recombinant human and simian adenoviral (AdHu5 and ChAd63) and orthopoxviral (MVA) vectors encoding transgene inserts for Plasmodium falciparum AMA1 (PfAMA1). METHODOLOGY/PRINCIPAL FINDINGS: AdHu5-MVA prime...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0020977

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Biswas, S
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Funding agency for:
Biswas, S
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Funding agency for:
Holder, A
Grant:
U117532067
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Funding agency for:
Gilbert, S
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Funding agency for:
Hill, A
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
6
Article number:
e20780
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
154023
Language:
English
Keywords:
Pubs id:
pubs:154023
UUID:
uuid:11dc1418-d75a-4490-a1aa-3a6fa7b508fc
Local pid:
pubs:154023
Deposit date:
2012-12-19

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