Comparative Epidemiology of <i>Salmonella</i> Paratyphi A and <i>Salmonella</i> Typhi Causing Enteric Fever, Bangladesh, 2018–2020

Journal article

Enteric fever remains a public health challenge. We analyzed (95% CI 41–117)/100,000 PY for paratyphoid and 887 (95% data from a cluster-randomized Vi-tetanus toxoid conjugate CI 715–1,088)/100,000 PY for typhoid. Lack of private toilets vaccine trial to compare the epidemiology between Salmo- and safe drinking water were associated with both diseases. nella enterica serovars Paratyphi A, which causes para- Prevalence of multidrug resistance was significantly higher typhoid fever, and Typhi, which causes typhoid fever. The in Salmonella Typhi (20.2%) than in Salmonella Paratyphi A overall incidence rate of paratyphoid fever was 27 (95% CI (0.8%) (p<0.001). Our data suggest that integrated control 23–32)/100,000 person-years (PY) and of typhoid fever was measures targeting water, sanitation, and hygiene measures 216 (95% CI 198–236)/100,000 PY. We observed the highest and bivalent vaccine targeting both pathogens are promising incidence for both diseases in children 2–4 years of age: 72 strategies to control both diseases.

Authors: Rahman, SIA; Firoj, MG; Park, SE; Khanam, F; Agampodi, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Centers for Disease Control and Prevention
• Journal: Emerging Infectious Diseases
• Volume: 31
• Issue: 10
• Pages: 1922-1934
• Publication date: 2025-09-30
• DOI: 10.3201/eid3110.241601
• EISSN: 1080-6059
• ISSN: 1080-6040
• Language: English
• Keywords: Paratyphoid fever; Salmonella enterica