Journal article
The new immunosuppression.
- Abstract:
- New knowledge on how lymphocytes become tolerant to antigens is now enabling novel tolerance-harnessing strategies to enter the clinical arena. In the field of transplantation, monoclonal antibodies used either to deplete lymphocytes or to block T-cell function can induce tolerance in mice and non-human primates. Understanding the mechanisms underlying tolerance should enable application to the clinic. Harnessing of tolerance mechanisms may enable more judicious use of conventional immunosuppressive agents even to the point of maintenance monotherapy, so limiting drug side effects and ensuring compliance.
- Publication status:
- Published
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- Publisher copy:
- 10.1016/s1367-5931(03)00076-0
Authors
- Journal:
- Current opinion in chemical biology More from this journal
- Volume:
- 7
- Issue:
- 4
- Pages:
- 476-480
- Publication date:
- 2003-08-01
- DOI:
- EISSN:
-
1879-0402
- ISSN:
-
1367-5931
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:16954
- UUID:
-
uuid:11d8e59d-b3b3-4a78-be7c-e076068abd92
- Local pid:
-
pubs:16954
- Source identifiers:
-
16954
- Deposit date:
-
2012-12-19
- ARK identifier:
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- Copyright date:
- 2003
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