Journal article
αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.
- Abstract:
-
Th17 cells are a distinct lineage of T helper cells that protect the body from bacterial and fungal infection. However, Th17 cells also contribute to inflammatory and autoimmune disorders such as multiple sclerosis. Th17 cell generation requires exposure of naive T cells to the cytokine TGF-β in combination with proinflammatory cytokines. Here we show that differentiation of Th17 cells is also critically dependent on αv integrins. In mice, lack of integrin αv in the immune system resulted in ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1172/jci43796
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Bibliographic Details
- Journal:
- The Journal of clinical investigation
- Volume:
- 120
- Issue:
- 12
- Pages:
- 4445-4452
- Publication date:
- 2010-12-05
- DOI:
- EISSN:
-
1558-8238
- ISSN:
-
0021-9738
- URN:
-
uuid:11c2eff8-7f5a-40f4-b005-390f4345cd43
- Source identifiers:
-
154028
- Local pid:
- pubs:154028
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 2010
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