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αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice.

Abstract:

Th17 cells are a distinct lineage of T helper cells that protect the body from bacterial and fungal infection. However, Th17 cells also contribute to inflammatory and autoimmune disorders such as multiple sclerosis. Th17 cell generation requires exposure of naive T cells to the cytokine TGF-β in combination with proinflammatory cytokines. Here we show that differentiation of Th17 cells is also critically dependent on αv integrins. In mice, lack of integrin αv in the immune system resulted in ...

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Publication status:
Published

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Publisher copy:
10.1172/jci43796

Authors


Acharya, M More by this author
Mukhopadhyay, S More by this author
Païdassi, H More by this author
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Journal:
The Journal of clinical investigation
Volume:
120
Issue:
12
Pages:
4445-4452
Publication date:
2010-12-05
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
URN:
uuid:11c2eff8-7f5a-40f4-b005-390f4345cd43
Source identifiers:
154028
Local pid:
pubs:154028

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