Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya.
BACKGROUND: Febrile malaria is the most common clinical manifestation of P. falciparum infection, and is often the primary endpoint in clinical trials and epidemiological studies. Subjective and objective fevers are both used to define the endpoint, but have not been carefully compared, and the relative incidence of clinical malaria by active and passive case detection is unknown. METHODS: We analyzed data from cohorts under active and passive surveillance, including 19,462 presentations wit...Expand abstract
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- Copyright 2010 Olotu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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