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Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya.

Abstract:

BACKGROUND: Febrile malaria is the most common clinical manifestation of P. falciparum infection, and is often the primary endpoint in clinical trials and epidemiological studies. Subjective and objective fevers are both used to define the endpoint, but have not been carefully compared, and the relative incidence of clinical malaria by active and passive case detection is unknown. METHODS: We analyzed data from cohorts under active and passive surveillance, including 19,462 presentations wit...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0015569

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
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Funding agency for:
Marsh, K
NIHR Biomedical Research Centre Oxford More from this funder
Deutsche Forschungsgemeinschaft More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS One Journal website
Volume:
5
Issue:
12
Pages:
Article: e15569
Publication date:
2010-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:11b8e4d5-1a90-4816-bed3-33080c10766f
Source identifiers:
112613
Local pid:
pubs:112613

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