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Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli

Abstract:

Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges. The permeation of antibiotics through the outer membrane is largely effected by the porin superfamily, changes in which contribute to antibiotic resistance. A series of antibiotic resistant E. coli isolates were obtained from a patient during serial treatment with various antibiotics. The sequence of OmpC changed at three positions during treatment giving rise to a total of four OmpC...

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Journal:
PLoS ONE
Volume:
6
Issue:
10
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
URN:
uuid:11b7908d-63ca-4f4b-a66b-72ad33a2a048
Source identifiers:
306231
Local pid:
pubs:306231
Language:
English

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