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Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis.

Abstract:

Raised serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, or IL-10 are associated with mortality in patients with sepsis, but it is not known whether elevated cytokine levels are independently predictive of mortality. Cytokine assays (TNF-alpha, IL-6, and IL-10) were performed on admission plasma samples from 172 adult Thai patients with severe melioidosis. Mortality was 31.4%. APACHE II score; septicemia; plasma lactate; TNF-alpha, IL-6, and IL-10 concen...

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Publication status:
Published

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Publisher copy:
10.1086/315271

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Volume:
181
Issue:
2
Pages:
621-625
Host title:
The Journal of infectious diseases
Publication date:
2000-02-01
Event location:
UNITED STATES
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Source identifiers:
37324

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