Prognostic value of cytokine concentrations (tumor necrosis factor-alpha, interleukin-6, and interleukin-10) and clinical parameters in severe melioidosis.

Conference item

Raised serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-6, or IL-10 are associated with mortality in patients with sepsis, but it is not known whether elevated cytokine levels are independently predictive of mortality. Cytokine assays (TNF-alpha, IL-6, and IL-10) were performed on admission plasma samples from 172 adult Thai patients with severe melioidosis. Mortality was 31.4%. APACHE II score; septicemia; plasma lactate; TNF-alpha, IL-6, and IL-10 concentrations; and IL-10/TNF-alpha and IL-6/IL-10 ratios were each associated with outcome (P

Authors: Simpson, A; Smith, MD; Weverling, G; Suputtamongkol, Y; Angus, B

• Publication status: Published
• Host title: The Journal of infectious diseases
• Volume: 181
• Issue: 2
• Pages: 621-625
• Publication date: 2000-02-01
• Event location: UNITED STATES
• DOI: 10.1086/315271
• EISSN: 1537-6613
• ISSN: 0022-1899
• Keywords: Lactates; Interleukin-10; Bacteremia; Cytokines; Biological Markers; Aged; Logistic Models; Aged, 80 and over; APACHE; Female; Male; Burkholderia pseudomallei; Ceftazidime; Thienamycins; Humans; Prognosis; Cephalosporins; Adolescent; Adult; Imipenem; Melioidosis; Tumor Necrosis Factor-alpha; Middle Aged; Interleukin-6